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Pancreatic stellate cells: what's new?
Tony C Y Pang1, Jeremy S Wilson, Minoti V Apte
1aPancreatic Research Group, South Western Sydney Clinical School, University of New South Wales bIngham Institute for Applied Medical Research, Liverpool, Australia.
Current Opinion in Gastroenterology
|June 8, 2017
Summary
Pancreatic stellate cells (PSCs) are key in pancreatitis and pancreatic cancer. Targeting PSCs and their functions offers new therapeutic strategies for these diseases.
Area of Science:
- Oncology
- Gastroenterology
- Cell Biology
Background:
- Pancreatic stellate cells (PSCs) are implicated in the development of pancreatitis and pancreatic cancer.
- Understanding PSCs is crucial for developing novel therapeutic approaches.
Purpose of the Study:
- To review recent advancements in understanding pancreatic stellate cell (PSC) biology.
- To explore the potential of targeting PSCs for therapeutic interventions in pancreatic diseases.
Main Methods:
- Literature review of recent studies on PSCs.
- Analysis of PSC interactions with the tumor microenvironment.
- Examination of intracellular signaling pathways within PSCs.
Main Results:
- PSCs interact with the extracellular matrix and stromal components.
- Intracellular calcium signaling in PSCs influences mechanical interactions and necrosis.
- Proinflammatory, protumoural, angiogenic, and metabolic pathways are linked to PSCs in pancreatic diseases.
- Stromal targeting shows potential for anticancer and antifibrotic effects.
Conclusions:
- Targeting PSCs presents a promising therapeutic avenue for pancreatitis and pancreatic cancer.
- Stromal reprogramming through PSC modulation offers new treatment opportunities.
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