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An engineering design approach to systems biology.

Kevin A Janes1, Preethi L Chandran, Roseanne M Ford

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA. kjanes@virginia.edu.

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Summary

This study proposes an engineering approach to systems biology, distinguishing basic and applied research. Training systems bioengineers can address modern biomedical challenges and boost industry impact.

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Area of Science:

  • Systems biology
  • Biomedical engineering
  • Quantitative biology

Background:

  • Systems biology integrates diverse disciplines but lacks distinction between basic and applied research.
  • This ambiguity blurs the field's aspirations and real-world impact potential.
  • Current approaches may not fully leverage biomedical Big Data.

Purpose of the Study:

  • To articulate and advocate for an engineering approach to systems biology.
  • To differentiate between basic and applied systems biology research.
  • To highlight the potential of systems bioengineering for industry.

Main Methods:

  • Applying educational philosophy and engineering design principles.
  • Utilizing predictive models for complex biomolecular-cellular networks.
  • Focusing on problem-solving within the context of biomedical Big Data.

Main Results:

  • An engineering framework for systems biology is proposed.
  • The approach emphasizes practical applications and real-world problem-solving.
  • Training in systems bioengineering is identified as crucial.

Conclusions:

  • An engineering approach clarifies systems biology's goals and impact.
  • Systems bioengineering offers a path to address industry challenges.
  • A specialized workforce is needed for biotechnology and pharmaceutical sectors.