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Updated: Mar 1, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
Published on: June 29, 2015
Total gastrectomy due to ferric chloride intoxication.
Ferric chloride intoxication, often accidental, is severely underestimated. This case highlights its caustic and toxic effects, necessitating emergency surgery due to gastric necrosis and perforation.
Area of Science:
- Toxicology
- Gastroenterology
- Emergency Medicine
Background:
- Ferric chloride intoxication is frequently accidental, with toxicity often underestimated, leading to severe consequences.
- The caustic nature of ferric chloride contributes significantly to its toxicity, linked to iron concentration.
Observation:
- A 36-year-old male presented with sensory deterioration, oral erosions, and metabolic acidosis.
- Elevated ferritin levels (1400 mg/dl) confirmed acute iron intoxication.
- CT scans revealed pneumoperitoneum and free fluid, indicating gastric necrosis and perforation.
Findings:
- The patient underwent exploratory laparotomy, total gastrectomy, esophagostomy, and feeding jejunostomy due to perforated gastric necrosis.
- Surgical intervention was necessitated by the severe caustic ingestion and subsequent complications.
Implications:
- This case underscores the critical need to recognize the severe toxicity of ferric chloride, even if infrequent.
- Prompt surgical intervention is crucial for managing complications like gastric necrosis and perforation in iron compound intoxication.
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