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Updated: Mar 1, 2026
Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
Published on: April 5, 2024
DNA damage in Wistar Kyoto rats exercised during pregnancy
Mikaela da Silva Corrêa1, Rafael Bottaro Gelaleti2, Giovana Fernanda Bento3
1Fellow Master degree, Postgraduate Program in Ginecology, Obstetrics and Mastology, Department of Gynecology and Obstetrics, Laboratory of Experimental Research in Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil. Scientific, intellectual, conception and design of the study; acquisition, analysis and interpretation of data; technical procedures; manuscript preparation.
Purpose::
To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program.
Methods::
Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage.
Results::
Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05).
Conclusion::
The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.
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