Related Experiment Video
Updated: Mar 1, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
[Risk factors associated with preterm birth in a second level hospital]
Beatriz Escobar-Padilla1, Limberg Darinel Gordillo-Lara, Horacio Martínez-Puon
1Coordinación de Educación e Investigación en Salud, Hospital General de Zona 2, Instituto Mexicano del Seguro Social, Tuxtla Gutiérrez, Chiapas, México. bety_escobar@hotmail.com.
Insights
Identifying risk factors for preterm birth is crucial. Placenta previa, previous preterm delivery, and preeclampsia significantly increase the risk of premature birth.
Area of Science:
- Obstetrics and Gynecology
- Perinatology
- Reproductive Health
Background:
- Preterm birth affects 10-11% of pregnancies, posing a significant challenge in obstetrics.
- Identifying risk factors is essential for prevention and management strategies.
Purpose of the Study:
- To identify key risk factors associated with preterm birth.
Main Methods:
- A retrospective, observational, case-control study involving 688 patients (344 cases of preterm birth and 344 controls).
- Statistical analysis included descriptive, univariate, and bivariate methods with Pearson chi-square test, odds ratios (OR), and 95% confidence intervals (95% CI).
Main Results:
- Significant risk factors identified include placenta previa (OR=10.2), previous preterm delivery (OR=10.2), preeclampsia (OR=6.38), twin pregnancy (OR=5.8), and oligohydramnios (OR=5.8).
- Other identified risk factors include tobacco use (OR=4.6), premature rupture of membranes (PROM) (OR=4.1), cervicovaginitis (OR=3), and urinary tract infections (UTI) (OR=1.5).
Conclusions:
- Maternal history, preeclampsia, PROM, twin pregnancy, placenta previa, cervicovaginitis, previous preterm delivery, and UTI are statistically significant risk factors for preterm delivery.
- These findings underscore the importance of monitoring these conditions to mitigate preterm birth risks.
Background:
Preterm birth is one of the biggest problems in obstetrics and gynecology, given that it has an incidence of 10-11%. The objective was to identify the risk factors associated with a preterm birth.
Methods:
A retrospective, observational, transversal and analytic case-control study was made. All premature birth incidences were determined as study objects and controls were integrated with term deliveries. A sample size of 344 patients with a control per case was calculated. A total of 688 patients were studied. Statistical analysis was descriptive, univariate and bivariate and we used the Pearson chi square test, with a p < 0.05, odds ratios (OR) and 95% confidence intervals (95% CI).
Results:
The risk factors associated with a preterm labor were placenta praevia: OR = 10.2 (p = 0.005); previous preterm delivery: OR = 10.2 (p = 0.005); preeclampsia: OR = 6.38 (p = 0.00); twin pregnancy: OR = 5.8 (p = 0.000); oligohydramnios: OR = 5.8 (p = 0.000); tobacco use: OR = 4.6 (p = 0.002); premature rupture of membranes (PROM): OR = 4.1 (p = 0.000); cervicovaginitis: OR = 3 (p = 0.000); urinary tract infections (UTI): OR = 1.5 (p = 0.010).
Conclusion:
Maternal history of prenatal care, preclampsia, PROM, twin pregnancy, placenta praevia, cervicovaginitis, previous preterm delivery and UTI are risk factors with statistical significance associated with preterm delivery.
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Type 2 and Gestational
Teratogenicity

