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Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET
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PLK1 Activation in Late G2 Sets Up Commitment to Mitosis.

Lilia Gheghiani1, Damarys Loew2, Bérangère Lombard2

  • 1Sorbonne Universités, UPMC University Paris 06, UFR927, 75005 Paris, France; CNRS UMR 8200, 94805 Villejuif, France; Gustave Roussy Cancer Campus, 94805 Villejuif, France.

Cell Reports
|June 8, 2017
PubMed
Summary

Polo-like kinase 1 (Plk1) is essential for cell cycle progression into mitosis. Plk1 activation, regulated by CyclinA2-Cdk, triggers Cdc25C phosphorylation, promoting entry into mitosis.

Keywords:
Cdc25CCyclinA2FRET biosensorG2 phasePlk1mitosis

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