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Updated: Mar 1, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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G Protein-Coupled Receptors Contain Two Conserved Packing Clusters

Omar B Sanchez-Reyes1, Aidan L G Cooke2, Dale B Tranter2

  • 1Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York.

Biophysical Journal
|June 8, 2017
PubMed
Summary

G protein-coupled receptors (GPCRs) utilize a conserved structural scaffold for proper folding and activation. Key residue clusters within their transmembrane helices are crucial for stability and signal responsiveness.

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