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Parainfluenza Virus in the Hospitalized Adult

Elliott Russell1, Michael G Ison1

  • 1Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 8, 2017
PubMed

Insights

Parainfluenza virus (PIV) causes respiratory illness in children and adults. While no approved treatments exist, an inhaled sialidase called DAS181 is in development for PIV infections.

Area of Science:

  • Virology
  • Respiratory Medicine

Background:

  • Parainfluenza virus (PIV) is a significant RNA virus impacting pediatric and immunocompromised individuals.
  • Its prevalence in hospitalized adults is increasingly recognized due to advanced diagnostic tools.

Purpose of the Study:

  • To highlight the varied clinical presentations of PIV in hospitalized adults.
  • To review the current treatment landscape and emerging therapeutic options for PIV infection.

Main Methods:

  • Review of clinical data and literature on PIV infections in hospitalized adults.
  • Analysis of the efficacy of Ribavirin and the development status of DAS181.

Main Results:

  • PIV presents with diverse symptoms, from upper to severe lower respiratory tract infections.
  • PIV is identified in 0.2%-11.5% of hospitalized pneumonia cases.
  • Ribavirin has shown no significant effect on PIV-related mortality.

Conclusions:

  • PIV poses a considerable threat to hospitalized adults, with varied clinical manifestations.
  • There is an unmet need for effective PIV treatments.
  • DAS181, an inhaled sialidase, represents a promising therapeutic candidate currently under clinical investigation.

Keywords:
DAS181parainfluenzapneumoniaribavirinvaccine

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