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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Published on: October 11, 2019
High expression of COX5B is associated with poor prognosis in breast cancer
Shui-Ping Gao1,2, He-Fen Sun1,2, Wen-Yan Fu1,2
1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Collaborative Innovation Center of Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Background:
Cytochrome c oxidase subunit VB (COX5B), a subunit of mammalian COX, takes roles in COX assembling and functions. Online database predicts high COX5B transcription may be associated with worse disease-free survival (DFS). However, the clinical implications of COX5B in breast cancer remain unclear.
Methods:
We carried out immunohistochemistry on tissue microarrays of 244 patients with invasive ductal breast carcinoma to detected COX5B expression.
Results:
Our results suggest that COX5B protein level might be associated with tumor size. COX5B overexpression indicated a worse DFS (p < 0.05) in breast cancer. Furthermore, high COX5B expression may act as an independent factor for worse DFS in breast cancer.
Conclusions:
Cumulatively, our findings suggest that COX5B might serve as an important prognostic factor for breast cancer.
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