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Related Experiment Video

Updated: Mar 1, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Grid Therapy: A Proof-of-Concept Study.

Thomas Henry1, Ana Ureba1, Alexander Valdman2

  • 1Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden.

Technology in Cancer Research & Treatment
|June 9, 2017
PubMed
Summary

Proton grid therapy merges proton and grid radiation techniques. This method is feasible for treating large abdominal tumors, offering dose uniformity similar to current methods while sparing surrounding tissues.

Keywords:
grid therapynew treatment methodproton grid therapyproton therapyspatially fractionated beamstreatment planning

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Area of Science:

  • Radiation Oncology
  • Medical Physics

Background:

  • Proton therapy offers precise dose delivery.
  • Grid therapy utilizes patterned radiation fields.
  • Combining these could benefit large tumor treatments.

Purpose of the Study:

  • To investigate the feasibility of proton grid therapy.
  • To evaluate its potential for treating abdominal cancers.
  • To assess dose distribution and tissue sparing.

Main Methods:

  • Treatment planning for two abdominal cancer patients.
  • Cross-firing proton beam arrays to form grids.
  • Optimizing beam fluence for target homogeneity and dose conformity.
  • Evaluating beam element shapes and sensitivity to setup errors.

Main Results:

  • Proton grid therapy is technically feasible with spot scanning systems.
  • Cross-firing from 4 directions achieved target doses of 100-130% of prescribed.
  • Dose distribution in surrounding tissue maintained low doses between beam paths.
  • Sensitivity analysis showed limited impact of setup errors with 4 beam arrays.

Conclusions:

  • Proton grid therapy is a viable technique for large solid tumors.
  • It allows for homogeneous target dose delivery and improved tissue sparing.
  • This approach is compatible with existing proton therapy infrastructure.