Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.7K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

2.3K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
2.3K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

19.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.3K
Mitochondria01:37

Mitochondria

21.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison between digital and physical anatomical specimens in a formative near-peer OSPE: Performance and perceptions in first-year medical students.

Anatomical sciences education·2026
Same author

Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience.

Cell·2025
Same author

High-pressure freezing of mechanically stretched cells.

Journal of microscopy·2025
Same author

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Correction: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.

eLife·2024
Same author

Inhibition of <i>CERS1</i> in skeletal muscle exacerbates age-related muscle dysfunction.

eLife·2024
Same journal

The lncRNA-m6A axis in cancer: a bidirectional regulatory network in tumor progression and therapeutic resistance.

Journal of translational medicine·2026
Same journal

Repurposing cepharanthine as a radiosensitizer in esophageal squamous cell carcinoma through dual metabolic intervention and direct targeting of p70s6K.

Journal of translational medicine·2026
Same journal

Cellular crosstalk and signaling networks in the rheumatoid arthritis synovial microenvironment.

Journal of translational medicine·2026
Same journal

Pilot spatial transcriptomics of dental pulpitis suggests immune-fibroblast profiling linked to reversibility.

Journal of translational medicine·2026
Same journal

Beyond semen analysis: in men with normal semen parameters telomere attrition and oxidative imbalance distinguish those fertile from those with infertility.

Journal of translational medicine·2026
Same journal

Dual-block HER2 assessment reveals clinically relevant intratumoral heterogeneity in gynecologic cancers: a single-center landscape analysis.

Journal of translational medicine·2026
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K

Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function.

Michel van Schaardenburgh1, Martin Wohlwend2, Øivind Rognmo2

  • 1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, PO box 8905, 7491, Trondheim, Norway. michel.van.schaardenburgh@ntnu.no.

Journal of Translational Medicine
|June 9, 2017
PubMed
Summary
This summary is machine-generated.

Exercise improves walking performance in intermittent claudication patients by enhancing mitochondrial function. Some patients respond negatively, showing decreased mitochondrial capacity, often linked to more severe peripheral arterial disease.

Keywords:
ExerciseIntermittent claudicationIschemia reperfusion injuryMitochondriaPreconditioning

More Related Videos

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.9K
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K

Related Experiment Videos

Last Updated: Mar 1, 2026

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K
Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.9K
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K

Area of Science:

  • Exercise physiology
  • Mitochondrial biology
  • Peripheral arterial disease

Background:

  • Exercise enhances walking performance in intermittent claudication (IC) patients.
  • Exercise may increase muscle mitochondrial enzyme activities, but responses vary among individuals.
  • Understanding individual mitochondrial responses to exercise is crucial for optimizing treatment.

Purpose of the Study:

  • To investigate the relationship between changes in walking performance and mitochondrial function after exercise in IC patients.
  • To identify subgroups of exercise responders (positive and negative) based on their mitochondrial capacity.
  • To explore factors associated with negative exercise response in IC.

Main Methods:

  • 28 IC patients underwent 8 weeks of either calf raising or walking exercise.
  • Measurements included walking performance, peripheral hemodynamics, and mitochondrial respiration and content (citrate synthase activity).
  • Multiple linear regression and paired t-tests were used to analyze changes in relation to exercise response subgroups.

Main Results:

  • Peak walking time changes correlated with mitochondrial respiration (ETF+CI, CI+ETF, CI+CII+ETF) and OXPHOS coupling efficiency in the overall group.
  • Negative responders (n=8) showed decreased mitochondrial respiration and OXPHOS efficiency, and had more advanced peripheral arterial disease.
  • Positive responders (n=8) demonstrated increased citrate synthase activity, indicating enhanced mitochondrial content.

Conclusions:

  • Exercise-induced changes in walking performance are linked to alterations in mitochondrial function in IC patients.
  • Negative responders experience a decrease in mitochondrial capacity, associated with more severe peripheral arterial disease.
  • Positive responders exhibit an increase in mitochondrial capacity, suggesting improved muscle energy metabolism.