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Thrombosis in diabetes: a shear flow effect?

Erik Westein1,2, Thomas Hoefer3, Anna C Calkin4,2

  • 1Vascular Biomechanics Group, Baker Heart and Diabetes Institute, Melbourne, Australia erik.westein@monash.edu.

Clinical Science (London, England : 1979)
|June 9, 2017
PubMed
Summary

Type 2 diabetes (T2D) increases cardiovascular risk due to heightened platelet reactivity. New research explores shear stress mechanisms in T2D thrombosis, seeking novel therapeutic targets beyond standard antiplatelet treatments.

Keywords:
DiabetesFigure 1 Blood cellsVWFaggregationdiabetesplateletsthrombosis

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Area of Science:

  • Cardiovascular Science
  • Thrombosis Research
  • Diabetes Complications

Background:

  • Type 2 diabetes (T2D) is linked to increased cardiovascular events and mortality.
  • Patients with T2D exhibit heightened platelet reactivity, leading to atherothrombotic risk and inadequate response to antiplatelet therapy.
  • Current understanding of shear stress in diabetes-associated thrombosis is limited, hindering effective therapeutic strategies.

Purpose of the Study:

  • To review limitations in assessing shear stress's role in T2D thrombus formation.
  • To discuss new technologies for understanding shear-dependent platelet activation in T2D.
  • To explore targeting shear-dependent mechanisms for novel T2D therapies.

Main Methods:

  • Literature review focusing on shear stress and thrombosis in Type 2 diabetes.
  • Analysis of limitations in current diagnostic and research models.
  • Discussion of recent technological advancements and their applications.

Main Results:

  • Current diagnostic systems inadequately assess shear stress in T2D, failing to replicate clinical pro-thrombotic phenotypes.
  • New technologies offer improved methods to define shear stress's importance in thrombus formation.
  • Understanding shear-dependent mechanisms presents a potential therapeutic avenue.

Conclusions:

  • Novel regulators of diabetes-associated thrombosis are needed.
  • Targeting shear-dependent mechanisms of thrombus formation shows promise for T2D treatment.
  • Further research using advanced technologies is crucial for developing effective therapies.