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Updated: Mar 1, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Blood Pressure Management for Stroke Prevention and in Acute Stroke
1Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Korea.
Insights
Lowering high blood pressure (BP) effectively reduces stroke risk. Intensive BP lowering offers greater vascular protection, especially for primary stroke prevention, but evidence for secondary prevention and acute stroke management varies.
Area of Science:
- Neurology
- Cardiology
- Public Health
Background:
- Elevated blood pressure (BP) is a primary modifiable risk factor for stroke.
- BP-lowering therapy significantly reduces stroke risk, but optimal targets remain debated.
- Existing evidence supports intensive BP lowering for enhanced vascular protection.
Purpose of the Study:
- To review current evidence on optimal BP management for stroke prevention.
- To examine BP targets for primary and secondary stroke prevention.
- To summarize BP management strategies in acute stroke settings.
Main Methods:
- Systematic review of epidemiological studies and randomized controlled trials (RCTs).
- Analysis of data on BP lowering for primary and secondary stroke prevention.
- Evaluation of evidence for BP management in acute intracerebral hemorrhage and ischemic stroke.
Main Results:
- Intensive BP lowering is beneficial for primary stroke prevention.
- Limited RCT evidence exists for intensive BP lowering in secondary stroke prevention.
- Guidelines recommend immediate BP lowering (systolic BP <140 mm Hg) in acute intracerebral hemorrhage.
- Early BP lowering is generally not recommended in acute ischemic stroke due to lack of proven benefit and potential harm.
Conclusions:
- Optimal BP targets vary depending on stroke type and prevention stage.
- Further research is needed for secondary stroke prevention BP targets.
- Current guidelines provide specific recommendations for acute stroke BP management.
Abstract:
Elevated blood pressure (BP) is the leading modifiable risk factor for stroke and the benefit of BP lowering therapy on the stroke risk reduction is well established. The optimal BP target for preventing stroke and other vascular events have been controversial, but the evidences from epidemiological studies and randomized controlled trials (RCTs) support intensive BP lowering for greater vascular protection, particularly for stroke prevention. For secondary stroke prevention, the evidence of intensive BP lowering benefit is limited since only a single RCT for patients with lacunar infarctions was conducted and most data were driven by exploratory analyses. In acute intracerebral hemorrhage, immediate BP lowering targeting systolic BP<140 mm Hg is recommended by guidelines based on the results from RCTs. In contrast, in acute ischemic stroke, early BP lowering is not usually recommended because of no benefit on functional outcome and future vascular events and potential harm of stroke progression. This review aims to summarize the updated evidence for optimal BP management for primary and secondary stroke prevention and in patients with acute stroke.
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