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Updated: Mar 1, 2026

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
MONITORING SLOWLY EVOLVING TUMORS
E Konukoglu1, W M Wells2, S Novellas1
1Asclepios Research Project, INRIA, Sophia Antipolis, France.
Abstract:
Change detection is a critical task in the diagnosis of many slowly evolving pathologies. This paper describes an approach that semi-automatically performs this task using longitudinal medical images. We are specifically interested in meningiomas, which experts often find difficult to monitor as the tumor evolution can be obscured by image artifacts. We test the method on synthetic data with known tumor growth as well as ten clinical data sets. We show that the results of our approach highly correlate with expert findings but seem to be less impacted by inter- and intra-rater variability.
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