Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Prognostic Value of Circulating Stem Cells Expressing PD-L1 in Patients with Hepatocellular Carcinoma.

Journal of hepatocellular carcinoma·2026

Same author

<i>Qipengyuania triglochinis</i> sp. nov. and <i>Alteriqipengyuania triglochinis</i> sp. nov.: two novel <i>Erythrobacteraceae</i> members isolated from rhizosphere and root in <i>Triglochin maritima</i> L.

International journal of systematic and evolutionary microbiology·2026

Same author

Counterion Effects of Protic Ionic Liquids on the Conductivity and Stretchability of Free-Standing PEDOT:PSS Films.

Macromolecules·2026

Same author

Finerenone increases the likelihood of improved KDIGO risk category in patients with CKD and type 2 diabetes: An analysis from FIDELITY.

Journal of diabetes and its complications·2026

Same author

Amikacin exposure and its association with ototoxicity and efficacy in nontuberculous mycobacterial pulmonary disease treatment.

Respiratory medicine·2026

Same author

Longitudinal monitoring of circulating tumor cell dynamics for potential prediction of early recurrence and clinical outcomes after curative resection of hepatocellular carcinoma: a pilot study.

BMC cancer·2026

Same journal

Demonstration of a quantum C-NOT gate in a time-multiplexed fully reconfigurable photonic processor.

Nature communications·2026

Same journal

Nonlinear quantum light source with van der Waals ferroelectric NbOX<sub>2</sub> (X = Br, I).

Nature communications·2026

Same journal

Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis.

Nature communications·2026

Same journal

The long tail of nitrate pollution in groundwater challenges governance of global water quality.

Nature communications·2026

Same journal

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026

Same journal

Warming climate has lengthened global intense tropical cyclone seasons.

Nature communications·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 1, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

Spaser as a biological probe.

Ekaterina I Galanzha¹, Robert Weingold¹, Dmitry A Nedosekin¹

¹Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

Nature Communications

|June 9, 2017

Summary

This summary is machine-generated.

Researchers developed a super-bright, biocompatible spaser (plasmonic nanolaser) probe for cellular imaging. This nanolaser generates stimulated emission within living cells, enabling enhanced diagnostics and therapies.

More Related Videos

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Published on: July 8, 2025

Membrane-SPINE: A Biochemical Tool to Identify Protein-protein Interactions of Membrane Proteins In Vivo

Membrane-SPINE: A Biochemical Tool to Identify Protein-protein Interactions of Membrane Proteins In Vivo

Published on: November 7, 2013

Related Experiment Videos

Last Updated: Mar 1, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Published on: July 8, 2025

Membrane-SPINE: A Biochemical Tool to Identify Protein-protein Interactions of Membrane Proteins In Vivo

Membrane-SPINE: A Biochemical Tool to Identify Protein-protein Interactions of Membrane Proteins In Vivo

Published on: November 7, 2013

Area of Science:

Biomedical Engineering
Nanotechnology
Cell Biology

Background:

Advanced diagnostic probes are crucial for understanding cell biology.
Existing probes like quantum dots have limitations in brightness and spectral width.

Purpose of the Study:

To introduce a novel 22-nm spaser (plasmonic nanolaser) as a super-bright, water-soluble, and biocompatible cellular probe.
To demonstrate its capability for generating stimulated emission within living cells and tissues.

Main Methods:

Development of a 22-nm spaser probe.
Demonstration of a lasing regime involving dynamic nanobubble formation.
Functionalization of the spaser surface with folic acid for targeted delivery.

Main Results:

Achieved giant spasing with >100x brighter emission and 30x narrower spectral width compared to quantum dots.
Enabled nanobubble-amplified photothermal and photoacoustic imaging and therapy.
Showcased molecular targeting of cancer cells using folic acid functionalization.

Conclusions:

The nanobubble spaser is a promising multimodal, super-contrast, ultrafast cellular probe.
It offers a single-pulse nanosecond excitation for diverse in vitro and in vivo biomedical applications.