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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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Cytologic perspectives on neoteric B-cell lymphoproliferative disorders.

Charles D Sturgis1, Sara E Monaco2, Hany Sakr1

  • 1Department of Pathology, Cleveland Clinic, Cleveland, OH.

Diagnostic Cytopathology
|June 9, 2017
PubMed
Summary

Cytopathologists need updated knowledge of the World Health Organization (WHO) lymphoma classification for diagnosing B-cell disorders. This review covers recent literature and diagnostic examples for seven newer B-cell neoplasms.

Keywords:
B-cellcytologyfine needle aspirationlymphoma

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Area of Science:

  • Hematopathology
  • Cytopathology
  • Oncology

Background:

  • The World Health Organization (WHO) classification of hematopoietic and lymphoid tissues undergoes revisions to reflect advancements in understanding lymphoproliferative disorders.
  • Cytopathologists play a crucial role in diagnosing primary, recurrent, and transformed lymphoproliferative disorders, necessitating familiarity with evolving diagnostic criteria.
  • An updated 2016 WHO classification is anticipated, requiring practitioners to be aware of changes in terminology, pathogenesis, and therapeutic approaches.

Purpose of the Study:

  • To provide cytopathologists with essential knowledge regarding updates to the WHO lymphoma classification, focusing on B-cell disorders.
  • To review the last decade of cytology-specific literature concerning seven newer B-cell neoplasms.
  • To present illustrative cytologic examples of these entities to aid in diagnosis.

Main Methods:

  • Literature review of cytology-specific publications from the past ten years.
  • Focus on seven recently recognized B-cell lymphoproliferative disorders.
  • Inclusion of diagnostic cytologic images from the authors' files.

Main Results:

  • Identification and review of key literature pertaining to the cytologic diagnosis of emerging B-cell lymphoproliferative disorders.
  • Detailed examination of terminology, pathogenesis, ancillary techniques, and targeted therapies for these entities.
  • Presentation of representative cytologic findings for each of the seven B-cell disorders discussed.

Conclusions:

  • Staying abreast of the evolving WHO lymphoma classification is critical for accurate cytologic diagnosis of B-cell lymphoproliferative disorders.
  • This review synthesizes current knowledge and provides practical examples to support cytopathologists in diagnosing newer B-cell entities.
  • Familiarity with these updates enhances diagnostic precision and informs appropriate patient management strategies.