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Related Concept Videos

Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Psychosis: Goals of Pharmacotherapy01:26

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Dosage Regimen: Fixed Dose01:01

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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Psychosis and Antipsychotic Drugs: Overview01:28

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Related Experiment Video

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Effect of an Institutional Medication Adherence Program for Long-Acting Injectable Risperidone on Adherence and

Jessica J Jalbert1,2, Michel Rossignol3,4, Bernard Astruc5

  • 1Analytica LASER, New York, NY, USA.

Journal of Population Therapeutics and Clinical Pharmacology = Journal De La Therapeutique Des Populations Et De La Pharmacologie Clinique
|June 9, 2017
PubMed
Summary

Reminder-based interventions for long-acting injectable antipsychotics improve adherence and reduce hospitalizations in schizophrenia patients. These programs are especially beneficial for individuals struggling with consistent medication schedules.

Keywords:
AdherenceAntipsychoticsHospitalizationMedication Adherence ProgramRelapseSchizophrenia

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Public Health

Background:

  • Long-acting injectable (LAI) antipsychotics enhance schizophrenia treatment adherence and decrease relapse rates.
  • Reminder-based interventions may offer additional benefits for patient outcomes.

Purpose of the Study:

  • To evaluate the effectiveness of an institutional medication adherence program (IMAP) on adherence and psychiatric hospitalizations.
  • Focus on schizophrenia patients receiving risperidone LAI (RLAI).

Main Methods:

  • A cohort study involving 506 schizophrenia patients treated with RLAI across 36 French psychiatric centers (2009-2010).
  • IMAP involved pre-injection reminders and follow-ups for missed appointments.
  • Centers were classified as IMAP compliant (≥50% adherence) or non-compliant.
  • One-year follow-up assessed adherence (≥80% RLAI received on time) and psychiatric hospitalizations.

Main Results:

  • IMAP compliance was linked to reduced psychiatric hospitalization rates (adjusted RR: 0.78).
  • Approximately 75% of patients demonstrated adherence to RLAI.
  • IMAP effectiveness was more pronounced in non-adherent patients (adjusted RR: 0.45) compared to adherent ones.

Conclusions:

  • Institutional medication adherence programs (IMAPs) show potential for improving patient adherence to LAI antipsychotics.
  • IMAPs may significantly reduce psychiatric hospitalizations, particularly for patients with adherence challenges.