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Related Experiment Video

Updated: Mar 1, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Accelerated versus conventional corneal crosslinking for refractive instability: an update.

George D Kymionis¹, George A Kontadakis, Kattayoon K Hashemi

¹aJules Gonin Eye Hospital, Faculty of Biology and Medicine, University of Lausanne, Lausanne, SwitzerlandbDepartment of Ophthalmology, 'Gennimatas Hospital', National and Kapoditrian University of Athensc'Ophthalmiatreio' Eye Hospital of Athens, Athens, Greece.

Current Opinion in Ophthalmology

|June 9, 2017

Summary

Accelerated corneal crosslinking (CXL) offers refractive stability comparable to the Dresden protocol for ectatic disorders. Further long-term studies are needed to confirm efficacy and determine optimal accelerated protocols.

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Area of Science:

Ophthalmology
Corneal Surgery
Refractive Error Correction

Background:

Corneal crosslinking (CXL) is a treatment for ectatic disorders.
The conventional Dresden protocol is time-consuming.
Accelerated CXL protocols have been developed to reduce procedure time.

Purpose of the Study:

To review and compare recent findings on accelerated CXL versus the conventional Dresden protocol.
To evaluate the safety and efficacy of accelerated CXL protocols.
To identify potential improvements for accelerated CXL.

Main Methods:

Literature review of studies comparing accelerated CXL protocols with the Dresden protocol.
Analysis of safety and efficacy data, including refractive stability.
Examination of indirect efficacy measures like demarcation line depth and laboratory results.

Main Results:

Initial studies suggest equivalent safety and efficacy for refractive stability between accelerated and conventional CXL.
Indirect measures of efficacy (demarcation line, lab data) do not consistently confirm equivalence.
There is a need for modified accelerated protocols to enhance efficacy.

Conclusions:

Accelerated CXL protocols appear to be a viable alternative to the conventional Dresden protocol.
Long-term comparative studies are essential to validate accelerated CXL.
Further research is required to determine the ideal accelerated protocol for specific patient cases.