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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Ozone-Related Respiratory Morbidity in a Low-Pollution Region
Sheryl Magzamen1, Brianna F Moore, Michael G Yost
1Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado (Drs Magzamen, Moore); Department of Environmental and Occupational Health Sciences (Drs Magzamen, Yost, Fenske, Karr); Department of Epidemiology (Dr Karr), University of Washington School of Public Health; Department of Pediatrics, University of Washington School of Medicine (Dr Karr), Seattle, Washington.
Objective:
We evaluated the effects of ozone on respiratory-related hospital admissions in three counties in Washington State from 1990 to 2006. We further examined vulnerability to ozone by key demographic factors.
Method:
Using linked hospital admission and ambient monitoring data, we estimated the age-, sex-, and health insurance-stratified associations between ozone (0 to 3 days' lag) and respiratory-related hospital admissions in King, Spokane, and Clark County, Washington.
Results:
The adjusted relative risk (RR) for a 10 ppb increase in ozone at 3 days' lag was 1.04 (95% confidence interval [CI]: 1.02, 1.07) for Clark County, 1.03 (95% CI: 1.01, 1.05) for Spokane County, and 1.02 (95% CI: 1.01, 1.03) for King County. There was consistent evidence of effect modification by age.
Conclusion:
Ozone at levels below federal standards contributes to respiratory morbidity among high-risk groups in Washington.
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