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Updated: Mar 1, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
Published on: November 22, 2021
Neural Manifolds for the Control of Movement
Juan A Gallego1, Matthew G Perich2, Lee E Miller3
1Department of Physiology, Northwestern University, Chicago, IL 60611, USA; Neural and Cognitive Engineering Group, Centre for Robotics and Automation CSIC-UPM, Arganda del Rey 28500, Spain.
Abstract:
The analysis of neural dynamics in several brain cortices has consistently uncovered low-dimensional manifolds that capture a significant fraction of neural variability. These neural manifolds are spanned by specific patterns of correlated neural activity, the "neural modes." We discuss a model for neural control of movement in which the time-dependent activation of these neural modes is the generator of motor behavior. This manifold-based view of motor cortex may lead to a better understanding of how the brain controls movement.
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