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Pre-β1 HDL in type 2 diabetes mellitus.

S W Shiu1, Y Wong1, K C Tan1

  • 1Department of Medicine, University of Hong Kong, Hong Kong.

Atherosclerosis
|June 9, 2017
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes significantly lowers pre-beta-1 HDL, a key molecule in cholesterol removal. This reduction impairs the body's ability to remove excess cholesterol, impacting reverse cholesterol transport.

Keywords:
ATP-binding cassette transporter A1Cardiovascular diseaseCholesterol effluxPre-β1 HDLType 2 diabetes

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Area of Science:

  • Lipid Metabolism
  • Cardiovascular Health
  • Endocrinology

Background:

  • Pre-beta-1 HDL (high-density lipoprotein) is crucial for reverse cholesterol transport, accepting free cholesterol from cells.
  • Understanding its role in type 2 diabetes is vital for managing cardiovascular risk.

Purpose of the Study:

  • To investigate pre-beta-1 HDL levels in type 2 diabetes patients, independent of HDL-cholesterol.
  • To assess the impact of altered pre-beta-1 HDL on cholesterol efflux capacity.

Main Methods:

  • Recruited 640 type 2 diabetic patients and 360 controls matched for HDL-cholesterol.
  • Measured plasma pre-beta-1 HDL using ELISA.
  • Assessed ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux using [3H]cholesterol transfer assays.

Main Results:

  • Diabetic patients showed significantly reduced pre-beta-1 HDL compared to controls, even with matched HDL-cholesterol.
  • Cardiovascular disease patients exhibited the lowest pre-beta-1 HDL levels.
  • Cholesterol efflux capacity was impaired in diabetics and correlated significantly with pre-beta-1 HDL levels.

Conclusions:

  • Type 2 diabetes is associated with decreased plasma pre-beta-1 HDL.
  • Reduced pre-beta-1 HDL is linked to impaired ABCA1-mediated cholesterol efflux.
  • Low pre-beta-1 HDL may contribute to defective reverse cholesterol transport in type 2 diabetes.