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Carla Teixeira Silva1, Ana Paula Carlos Cândido, Daniela Pala

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Cardiovascular risk factors in adolescents are linked to inflammation. Lipid metabolism alterations show a strong association with inflammatory markers, suggesting early cardiovascular disease development.

Keywords:
AdolescentsCardiovascular diseaseCytokinesPrincipal components analysisRisk factors

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Area of Science:

  • Adolescent health
  • Cardiovascular disease research
  • Inflammation and metabolism

Background:

  • Cardiovascular risk (CVR) factor clusters increase cardiovascular disease (CVD) risk.
  • Understanding these associations in adolescents is crucial for early intervention.

Purpose of the Study:

  • To assess associations between CVR factor clusters and inflammatory markers in Brazilian adolescents.
  • To investigate gender-specific differences in these relationships.

Main Methods:

  • Cross-sectional study of 487 adolescents (12.06 ± 1.41 years).
  • Measurements included anthropometric, clinical, biochemical, and inflammatory markers.
  • Principal component analysis identified 5 independent CVR factor clusters.

Main Results:

  • Glucose metabolism inversely associated with interleukin-1β (IL-1β) in both genders.
  • Blood pressure inversely associated with tumor necrosis factor alpha (TNF-α) in girls.
  • Lipid metabolism (HDL/TG) showed varied associations with IL-6, IL-1β, TNF-α, and adiponectin, with stronger links in boys.

Conclusions:

  • Lipid metabolism alterations are strongly linked to inflammation in adolescents.
  • These findings suggest lipid alterations may be early events in CVD development.
  • Inflammatory links differ across CVR factor clusters.