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The relationship between serum lipid parameters and renal frame count in hypertensive patients with normal renal

Emrah İpek1, Mustafa Yolcu, Erkan Yıldırım

  • 1Department of Cardiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey. dremrah21@yahoo.com.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|June 9, 2017
PubMed

Insights

High cholesterol levels, indicated by elevated low-density lipoprotein (LDL) and total cholesterol (TC), are linked to increased renal frame count (RFC) in hypertensive patients. Aggressive risk factor modification may help reduce renal failure risk.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • Atherosclerosis contributes to renovascular disease, with high cholesterol being a key risk factor.
  • Renal frame count (RFC) quantifies macrovascular blood flow in renal arteries.
  • Understanding the link between lipids and renal blood flow is crucial for managing renovascular disease.

Purpose of the Study:

  • To investigate the relationship between serum lipid parameters (LDL and TC) and RFC in hypertensive patients.
  • To identify predictors of elevated RFC in this patient population.

Main Methods:

  • A cross-sectional study involving 116 hypertensive patients.
  • Patients were grouped based on serum low-density lipoprotein (LDL <130 mg/dL vs. ≥130 mg/dL) and total cholesterol (TC <200 mg/dL vs. ≥200 mg/dL) levels.
  • Renal frame count (RFC) was measured using an angiographic method.

Main Results:

  • Higher mean RFC was observed in patients with elevated LDL and TC levels (p<0.001).
  • RFC showed a positive correlation with smoking, TC, and LDL.
  • Multivariate analysis identified LDL, TC, smoking, and creatinine clearance as independent predictors of RFC.

Conclusions:

  • Elevated LDL, TC, and smoking are potential predictors of RFC in hypertensive patients with normal renal function.
  • Aggressive modification of these risk factors may be beneficial in reducing the risk of renal failure.
Abstract

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