Related Experiment Video
Updated: Mar 1, 2026
08:13
Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion
Published on: January 20, 2019
7.2K
Validating Multi-Dimensional Outcome Assessment Using the Traumatic Brain Injury Common Data Elements: An Analysis of
Lindsay D Nelson1, Jana Ranson2, Adam R Ferguson3
1Departments of Neurosurgery & Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Journal of Neurotrauma
|June 10, 2017
Summary
The Glasgow Outcome Scale-Extended (GOSE) may miss mild traumatic brain injury (TBI) deficits. This study shows TBI recovery is multidimensional, requiring more than one outcome measure for accurate assessment.
Area of Science:
- Neuroscience
- Clinical Trials
- Traumatic Brain Injury Research
Background:
- The Glasgow Outcome Scale-Extended (GOSE) is a primary outcome in traumatic brain injury (TBI) clinical trials.
- Concerns exist regarding GOSE's sensitivity to mild disability and its comprehensive capture of post-TBI issues.
Purpose of the Study:
- To examine the alignment of disability ratings across multiple outcome domains in the TRACK-TBI Pilot study.
- To assess the limitations of using a single outcome measure for TBI recovery.
Main Methods:
- Analysis of data from the TRACK-TBI Pilot study, collecting TBI Common Data Elements (CDE) measures.
- Prospective enrollment of TBI patients across three emergency departments, with outcome measures at 3 and 6 months post-injury.
- Examination of impairment frequency and overlap across GOSE, neurocognitive, psychological, TBI symptoms, and quality of life domains.
Main Results:
- GOSE scores showed expected correlations with neurocognitive (rho=.21) and self-report outcomes (rho=.49).
- Even patients in the highest GOSE category (8) exhibited executive functioning deficits (19.0%).
- A significant portion of patients in the lower GOSE category (7) showed impairments across multiple domains.
Conclusions:
- Traumatic brain injury recovery is inherently multidimensional.
- Relying solely on the GOSE may underestimate the full spectrum of patient disability after TBI.
- A comprehensive assessment using multiple outcome measures is crucial for accurately evaluating TBI recovery.
