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Targeted Drug Delivery Systems and Their Therapeutic Applications in Cancer and Immune Pathological Conditions

Jamshed Iqbal1, Fareeha Anwar2, Saifullah Afridi1

  • 1Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, Abbottabad-22060. Pakistan.

Infectious Disorders Drug Targets
|June 10, 2017
PubMed
Abstract

Insights

This review explores advanced drug delivery systems to minimize chemotherapy side effects. It highlights innovations in targeted therapy, aiming for selective drug action against diseased cells while sparing healthy tissues.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • The concept of targeted drug delivery, or
  • magic bullet
  • dates back over a century.
  • Significant progress has been made in targeted drug delivery, but reducing toxic effects on healthy cells remains a challenge.
  • This survey focuses on recent drug delivery systems to mitigate chemotherapy's adverse effects on healthy tissues.

Purpose of the Study:

  • To review recent advancements in targeted drug delivery systems.
  • To explore techniques for selective drug delivery to specific diseased cells or tissues.
  • To cover modern techniques for carrier-drug systems that precisely target diseased cells.

Main Methods:

  • Literature review of state-of-the-art targeted drug delivery technologies.
  • Analysis of advances, benefits, and limitations of various drug delivery platforms.
  • Survey of systems including hydrogels, microfluidics, nanoparticles, and more.

Main Results:

  • Identified various advanced drug delivery systems for targeted therapy.
  • Highlighted the potential of these systems to improve drug selectivity.
  • Discussed the benefits and limitations associated with each technology.

Conclusions:

  • Targeted drug delivery systems offer promising strategies to reduce chemotherapy toxicity.
  • Hydrogels, microfluidics, nanoparticles, carbon nanotubes, polymeric micelles, liposomes, lipoprotein-based carriers, and dendrimers represent key areas of advancement.
  • Further research is needed to overcome the limitations and fully realize the potential of these targeted delivery methods.
Keywords:
Cancer therapydrug carriershydrogelsnanoparticlespolyoxometalatetargeted drug delivery.

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