Related Experiment Video
Updated: Feb 28, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Cancer mortality in patients with schizophrenia: systematic review and meta-analysis
Chuanjun Zhuo1, Ran Tao2, Ronghuan Jiang2
1Chuanjun Zhuo, MD, PhD, Department of Psychiatry, Wenzhou Seventh people's Hospital, Wenzhou, Zhejiang and Department of Psychiatry, Tianjin Anding Hospital, Hexi District and Dongli District, Tianjin, China; Ran Tao, MD, Department of Psychiatry, Chinese PLA (people's Liberation Army) Hospital, Dongzhimen, Dongcheng District, Beijing; Ronghuan Jiang, MD, Department of Psychiatry, Chinese PLA (People's Liberation Army) Medical School, Haidian District, Beijing; Xiaodong Lin, MD, Department of Psychiatry, Wenzhou Seventh people's Hospital, Wenzhou, Zhejiang, China; Mingjing Shao, MD, Department of Psychiatry, Chinese PLA (People's Liberation Army) Medical School, Haidian District, Beijing, China chuanjunzhuotjmh@163.com.
Abstract:
BackgroundPrevious studies have reported conflicting results on the association between schizophrenia and cancer mortality.AimsTo summarise available evidence and quantify the association between schizophrenia and cancer mortality using meta-analysis.MethodWe systematically searched literature in the PubMed and Embase databases. Risk estimates and 95% confidence intervals reported in individual studies were pooled using the DerSimonian-Laird random-effects model.ResultsWe included 19 studies in the meta-analysis. Among them, 15 studies reported standardised mortality ratios (SMRs) comparing patients with schizophrenia with the general population, and the pooled SMR was 1.40 (95% CI 1.29-1.52, P < 0.001). The other four studies reported hazard ratios (HRs) comparing individuals with schizophrenia with those without schizophrenia; the pooled HR was 1.51 (95% CI 1.13-2.03, P = 0.006).ConclusionsPatients with schizophrenia are at a significantly increased risk of cancer mortality compared with the general population or individuals without schizophrenia.
Related Concept Videos
Cancer Survival Analysis
Psychological and Sociocultural Causes of Schizophrenia
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Schizophrenia
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Psychoneuroimmunology: Diabetes and Cancer