Enoxaparin Induced Skin Lesions in Pregnancy: A Rare But Clinically Recognizable Association

We report the case of a 29 year old pregnant female who experienced itching with erythematous plaques on prophylactic enoxaparin for recurrent fetal losses. These lesions generalized on rechallenge but erythema and itching gradually resolved after 4 weeks of discontinuation. Cutaneous adverse events with heparin have been reported (Villanueva et al. in Actas Dermosifiliogr 103:816-819, 2012; Neloska et al. in Acta Dermatovenerol Croat 23:223-224, 2015; Maldonado et al. in Clin Exp Dermatol 37:707-711, 2012; Schindewolf et al. in Lancet 380:1867-1879, 2012; Tassava and Warkentin in Am J Hematol 90:747-750, 2015), some specifically with enoxaparin (Villanueva et al. 2012; Neloska et al. 2015).