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A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles
Ferran Casbas Pinto1,2, Srinivarao Ravipati2, David A Barrett2
1School of Biosciences, University of Nottingham, Sutton Bonington, LE12 5RD UK.
Introduction:
It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations.
Objectives:
This work simplifies this process.
Methods:
A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways that connect the input list of lipids.
Results:
The output enables pathway visualisation and the querying of other databases to identify potential regulators. When used to a study a plasma lipidome dataset of polycystic ovary syndrome, 14 enzymes were identified, of which 3 are linked to ELAVL1-an mRNA stabiliser.
Conclusion:
This method provides a simplified approach to identifying potential regulators causing lipid-profile perturbations.
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