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Lung Organoids and Their Use To Study Cell-Cell Interaction.

Marko Z Nikolić1, Emma L Rawlins1

  • 1Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN UK.

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Lung organoids are revolutionizing cell-cell interaction studies. While airway basal cell organoids are established, other lung region organoid development, crucial for understanding stem cell niches, is emerging.

Keywords:
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Area of Science:

  • Pulmonary research
  • Stem cell biology
  • Organoid technology

Background:

  • Organoids are increasingly utilized in lung research to investigate cell-cell interactions.
  • Current organoid models are well-established for airway basal cells.
  • Organoid development for other lung regions remains nascent.

Purpose of the Study:

  • To review the advancements in lung organoid technology for studying cell-cell interactions.
  • To highlight the potential of organoids in understanding lung stem cell biology.
  • To discuss future directions in lung organoid development.

Main Methods:

  • Co-culture systems are employed to cultivate lung stem cell populations.
  • Organoid cultures rely on interactions between stem cells and niche cells.
  • Analysis focuses on dissecting molecular requirements for cell-cell interactions.

Main Results:

  • Co-culture organoid systems enable in vitro cultivation of previously inaccessible stem cell populations.
  • These systems provide a novel platform for studying cell-cell interactions in the lung.
  • Organoid development for non-airway basal cell regions is still in early stages.

Conclusions:

  • Lung organoids offer a powerful tool for dissecting cell-cell interactions in vitro.
  • Future advancements aim for epithelial-only organoids in defined media and inclusion of specific non-epithelial cells.
  • A deeper understanding of lung cell types and lineage relationships is essential for future organoid development.