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A commingling analysis of obesity in the Tecumseh community health study
M A Province1, J Keller2, M Higgins2
1Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110.
Abstract:
A commingling analysis of the distributions of obesity as quantified by Quetelet's index, triceps skinfold, suprailiac skinfold, umbilical skinfold, subscapular skinfold, a trunk-extremity ratio of skinfold measurements and Quetelet-adjusted trunk-extremity ratio was performed in a population of 9,226 individuals living in Tecumseh, Michigan, during 1962-1965. For all but the (non-Quetelet-adjusted) trunk-extremity ratio, two or three distributions were needed to fit the data adequately even after performing a power transformation to eliminate skewness. Although this evidence is compatible with a major gene effect, segregation analyses of these data using the unified, mixed model are necessary to resolve whether the commingling is due to a major gene.
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