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MicroRNAs in HPV associated cancers: small players with big consequences
Sandeep Satapathy1, Jyotsna Batra2,3,4, Varinder Jeet2,3,4
1a Department of Biological Sciences , Indian Institute of Science Education and Research , Bhopal , India.
Expert Review of Molecular Diagnostics
|June 10, 2017
Summary
Dysregulated microRNAs (miRs) play a key role in Human Papillomavirus (HPV)-associated cancers. These miRs show potential as diagnostic biomarkers in bodily fluids and targets for novel cancer therapies.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- MicroRNAs (miRs) are short non-coding RNAs regulating crucial cellular functions.
- Dysregulated miRs are implicated in various cancers, including Human Papillomavirus (HPV)-associated malignancies.
- Specific miRs like -143, -375, -21, -200, and -296 are identified as dysregulated in HPV-associated cancers.
Purpose of the Study:
- To review the involvement of specific miRs in HPV-associated cancers.
- To explore the potential of intracellular and exosomal miRs as diagnostic biomarkers in saliva and blood.
- To analyze the functional impact of miRs on cellular processes contributing to cancer development.
Main Methods:
- Literature review of studies on miRs in HPV-associated cancers.
- Analysis of intracellular and exosomal miR expression patterns.
- Examination of functional roles of miRs in cellular polarity, apoptosis, and cell cycle regulation.
Main Results:
- Identified specific miRs (-143, -375, -21, -200, -296) as dysregulated in HPV-associated cancers.
- Highlighted the potential of both intracellular and exosomal miRs as diagnostic biomarkers in saliva and blood.
- Dissected the functional impact of miRs on cellular processes leading to uncontrolled proliferation.
Conclusions:
- Dysregulated miRs in HPV-associated cancers offer new avenues for diagnostic, therapeutic, and prognostic biomarkers.
- Global expression profiling of these miRs can inform broader therapeutic strategies.
- Development of miR-targeting therapies (anti-miR, miR-replacement) requires improvement for cost-effectiveness and better outcomes.
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