Related Experiment Video

Updated: Feb 28, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.8K

The regulatory role of miRNAs on VDR in breast cancer

Tatyana Singh1, Brian D Adams1,2,3

  • 1a State University of New York - University at Albany , Albany , NY , USA.

Transcription
|June 10, 2017
PubMed

Insights

This study explores the role of vitamin D receptor (VDR) and microRNAs (miRNAs) in triple-negative breast cancer (TNBC). Researchers found specific miRNAs may regulate VDR, potentially impacting breast cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER), progesterone receptor (PR), and HER-2, but expresses other receptors like vitamin D receptor (VDR).
  • The function of VDR and the role of microRNAs (miRNAs), which regulate gene silencing, in TNBC are not well understood.
  • Altered miRNA expression is observed in breast cancer compared to normal mammary cells.

Purpose of the Study:

  • To investigate the potential correlation between vitamin D receptor (VDR) levels and specific microRNAs (miRNAs) implicated in breast cancer.
  • To explore the role of miRNAs in regulating VDR activity within the context of breast cancer development and tumorigenesis.

Main Methods:

  • Literature review on miRNAs in breast cancer.
  • In silico analysis to assess the relationship between VDR levels and key breast cancer-related miRNAs.
  • Identification of significant miRNAs involved in VDR regulation.

Main Results:

  • Three specific miRNAs (miR-23, miR-124, and miR-125) were identified as potentially significant.
  • Evidence suggests these miRNAs may play a role in controlling vitamin D receptor (VDR) activity.
  • A possible link between miRNA-mediated VDR regulation and breast cancer development was established.

Conclusions:

  • Specific miRNAs, including miR-23, miR-124, and miR-125, may be crucial regulators of VDR.
  • These miRNAs could influence the development and progression of breast cancer by modulating VDR.
  • Further research into miRNA-VDR interactions is warranted for understanding TNBC pathogenesis.
Keywords:
VDRbiomarkerbreast cancermiR-125miRNAstreatment resistancetumor suppressor

More Related Videos

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.1K
Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

7.1K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.9K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K