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Molecularly targeted agents in oculoplastic surgery

Richard C Allen1

  • 1Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Current Opinion in Ophthalmology
|June 10, 2017
PubMed
Abstract

Insights

Molecularly targeted agents (MTAs), including monoclonal antibodies and small molecule inhibitors, are revolutionizing cancer and rheumatology care. Their expanding applications in orbital, lacrimal, and eyelid diseases offer new therapeutic avenues for oculoplastic surgeons.

Area of Science:

  • Oncology
  • Rheumatology
  • Ophthalmology
  • Oculoplastics

Background:

  • Molecularly targeted agents (MTAs) have significantly advanced oncology and rheumatology treatments.
  • MTAs encompass monoclonal antibodies and small molecule inhibitors.
  • Oculoplastic surgery is increasingly impacted by these novel therapeutic agents.

Purpose of the Study:

  • To review the recent applications of MTAs in orbital, lacrimal, and eyelid diseases.
  • To highlight the role of MTAs in treating oncologic and inflammatory conditions affecting the eye and its adnexa.
  • To inform oculoplastic surgeons about the evolving use of MTAs.

Main Methods:

  • Literature review of recent studies on MTAs in oculoplastic applications.
  • Analysis of therapeutic uses in orbital, lacrimal, and eyelid conditions.
  • Identification of side effects associated with MTAs in this patient population.

Main Results:

  • Monoclonal antibodies are used for orbital vascular lesions, lymphoma, squamous cell carcinoma, thyroid eye disease, IgG4 disease, and granulomatosis with polyangiitis.
  • Immunotherapy with checkpoint inhibitors shows promise in orbital disease.
  • Small molecule inhibitors are applied to basal cell carcinoma, squamous cell carcinoma, and Erdheim-Chester disease.
  • Common side effects include hypertrichosis, edema, and inflammation of the orbit and eyelids.

Conclusions:

  • MTAs are the future of oncologic and inflammatory condition treatment.
  • The application of MTAs in oculoplastic diseases is expected to grow.
  • Understanding molecular mechanisms will unlock new therapeutic targets for oculoplastic disorders.

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