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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Cutaneous sarcoidosis.

Megan H Noe1, Misha Rosenbach

  • 1aDepartment of Dermatology bDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Current Opinion in Pulmonary Medicine
|June 10, 2017
PubMed
Summary
This summary is machine-generated.

Cutaneous sarcoidosis, a rare skin condition, is more common in women and can be triggered by new factors. Effective treatments are still limited, highlighting the need for further research.

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Area of Science:

  • Dermatology
  • Immunology
  • Epidemiology

Background:

  • Cutaneous sarcoidosis affects up to 30% of sarcoidosis patients, often as the initial symptom.
  • This rare skin disease has poorly understood presentation and treatment aspects.
  • Recent advancements offer insights into its epidemiology, clinical features, diagnosis, and management.

Purpose of the Study:

  • To review recent developments in cutaneous sarcoidosis.
  • To highlight new findings in epidemiology, clinical presentation, diagnosis, and treatment.
  • To provide an overview of the current understanding and future directions in managing this condition.

Main Methods:

  • Review of recent epidemiological studies.
  • Analysis of emerging clinical presentations and associations.
  • Evaluation of diagnostic imaging techniques and treatment strategies.

Main Results:

  • Cutaneous sarcoidosis is more prevalent in women and often signals systemic disease.
  • New associations with oncologic immune modulators are observed.
  • Ultrasound shows potential for assessing cutaneous granulomas and treatment response.
  • Validated cutaneous scoring tools may facilitate higher-quality research.

Conclusions:

  • Recent research identified new triggers for cutaneous sarcoidosis.
  • Evidence for effective treatments remains limited.
  • Further research is essential to enhance patient care for cutaneous sarcoidosis.