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Published on: November 23, 2016
Angupyrones A - E, α-Pyrone Analogues with ARE-Activation from a Sponge-Associated Fungus Truncatella angustata
Yang Zhao1, Dong Liu1, Peter Proksch2
1State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
Abstract:
TLC-DPPH guided fractionation of a sponge-associated fungus Truncatella angustata with a solid culture resulted in the isolation of five new α-pyrone-based analogues namely angupyrones A - E (1 - 5), and 3-ethyl-4-hydroxy-6-methyl-2-pyrone. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method, bulkiness rule, and specific rotation for the configurational assignments. Angupyrones A - E exhibited moderate antioxidant response element activation in HepG2C8 cells, while the preliminary structure-activity relationship was discussed.
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