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Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis
Zhiwei Zhao1, Shichao Wang1,2, Yingbo Lin3
1West China Medical Center, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Abstract:
Epithelial-mesenchymal transition (EMT) is a biological process that is associated with cancer metastasis and invasion. In cancer, EMT promotes cell motility, invasion and distant metastasis. Interleukin (IL)-8 is highly expressed in tumors and may induce EMT. The IL-8/IL-8R axis has a vital role in EMT in carcinoma, which is regulated by several signaling pathways, including the transforming growth factor β-spleen associated tyrosine kinase/Src-AKT/extracellular signal-regulated kinase, p38/Jun N-terminal kinase-activating transcription factor-2, phosphoinositide 3-kinase/AKT, nuclear factor-κB and Wnt signaling pathways. Blocking the IL-8/IL-8R signaling pathway may be a novel strategy to reduce metastasis and improve patient survival rates. This review will cover IL-8-IL-8R signaling pathway in tumor epithelial-mesenchymal transition.
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