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Acoustic force measurements on polymer-coated microbubbles in a microfluidic device.

Gianluca Memoli1, Christopher R Fury1, Kate O Baxter1

  • 1Department of Acoustics, National Physical Laboratory, Hampton Road, Teddington TW11 0LW, United Kingdom.

The Journal of the Acoustical Society of America
|June 11, 2017
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Summary

This study introduces an acoustofluidic device for precise microbubble manipulation using combined optical and acoustic tweezers. It details methods for accurate acoustic pressure measurement, crucial for biomedical applications.

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Area of Science:

  • Acoustofluidics
  • Biophysics
  • Optical Tweezers

Background:

  • Microbubble manipulation is vital for various biomedical applications.
  • Precise characterization of acoustic fields is essential for controlling microbubbles.

Purpose of the Study:

  • To develop and characterize an acoustofluidic device for manipulating coated microbubbles.
  • To enable simultaneous use of optical and acoustic tweezers for precise control.

Main Methods:

  • Combined use of laser vibrometry, finite element modeling, and holographic optical tweezers.
  • Particle tracking with polystyrene beads for quantitative acoustic pressure measurements.
  • Extension of tracking to microbubbles with negative acoustophoretic contrast factor.

Main Results:

  • Comprehensive characterization of acoustic pressure within the device.
  • Accurate measurement of acoustic forces acting on isolated microbubbles.
  • Identification of four distinct peaks in the device's acoustic response.

Conclusions:

  • The developed device and methodologies allow precise acoustic field characterization.
  • Results are applicable to acoustofluidic and biomedical applications involving microbubbles or deformable particles.