Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

1.0K
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
1.0K
Bacterial Signaling01:30

Bacterial Signaling

42.2K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
42.2K
Antimicrobial Proteins01:23

Antimicrobial Proteins

14.8K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms and impact of long COVID: pathophysiology, neuropsychiatric effects and vaccination.

Frontiers in immunology·2026
Same author

Modulation of the immunogenic landscape in colorectal cancer by mitochondrial methylation-controlled J protein.

Molecular biomedicine·2026
Same author

Targeting protein protein interactions and their modulators to enable new therapeutic strategies for human diseases.

NPJ systems biology and applications·2026
Same author

Differential responses to the combination of navitoclax and venetoclax with doxorubicin in murine models of triple negative breast cancer.

Frontiers in cell and developmental biology·2026
Same author

The Prothrombotic Phenotype of Thirdhand Electronic Cigarette Exposure is Sex Independent and Involves Systemic Mediated Effects on Platelet Function: Evidence from a Mouse Model.

Cardiovascular toxicology·2026
Same author

A systems biology approach to unveil shared therapeutic targets and pathological pathways across major human cancers.

Computational and structural biotechnology journal·2025

Related Experiment Video

Updated: Feb 28, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

4.0K

Metallic nanoparticles to eradicate bacterial bone infection.

Shahnaz Qadri1, Yousef Haik1, Eric Mensah-Brown2

  • 1College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar.

Nanomedicine : Nanotechnology, Biology, and Medicine
|June 11, 2017
PubMed
Summary

Silver-copper-boron nanoparticles effectively treated Staphylococcus aureus bone infections in mice, eliminating 99% of bacteria. This metallic nanoparticle approach offers a promising, non-toxic alternative to conventional antibiotics for osteomyelitis.

Keywords:
Ag-Cu-BAnimal modelIn vivoNanoparticlesOsteomyelitis

More Related Videos

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

3.0K
Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
05:57

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

1.4K

Related Experiment Videos

Last Updated: Feb 28, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

4.0K
Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

3.0K
Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
05:57

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

1.4K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Infectious Diseases

Background:

  • Osteomyelitis treatment is challenging due to poor antibiotic penetration to bone tissue.
  • In vivo applications of inorganic antimicrobials are underexplored.
  • Multidrug-resistant bacteria necessitate novel therapeutic strategies.

Purpose of the Study:

  • To evaluate the efficacy of silver-copper-boron composite nanoparticles for treating Staphylococcus aureus osteomyelitis.
  • To assess the in vivo antimicrobial activity and safety of these nanoparticles.

Main Methods:

  • Development and characterization of silver-copper-boron composite nanoparticles.
  • Induction of osteomyelitis in a mouse model.
  • Intravenous (i.v.) and intramuscular (i.m.) administration of nanoparticles at a 1mg/kg dose.

Main Results:

  • A 99% reduction in bacterial load was observed in the induced osteomyelitis mouse model.
  • Nanoparticle administration via i.v. or i.m. routes demonstrated significant efficacy.
  • The 1mg/kg dose showed no toxicity or adverse immune response.

Conclusions:

  • Silver-copper-boron composite nanoparticles are effective in eradicating Staphylococcus aureus bone infections.
  • Metallic nanoparticles represent a viable and safe alternative to antibiotics for osteomyelitis treatment.
  • Further research into nanoparticle-based therapies for bone infections is warranted.