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Published on: January 31, 2018
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Changes in pre- and post-donation platelet function in plateletpheresis donors.
1Blood Donation Serving Section II, Beijing Red Cross Blood Center, No. 37, North Sanhuanzhong Road, 100088 Beijing, Haidian District, China.
Summary
Platelet donation temporarily impacts platelet function and coagulation but returns to normal levels within 14 days. Donation frequency does not affect these parameters or iron levels in healthy donors.
Area of Science:
- Hematology
- Transfusion Medicine
Background:
- Plateletpheresis is a vital donation method for patients requiring platelet transfusions.
- Understanding the impact of donation frequency on donor physiology is crucial for donor safety and retention.
Purpose of the Study:
- To investigate the transient effects of plateletpheresis donation on platelet function and coagulation parameters.
- To assess if the frequency of platelet donation influences these physiological changes in healthy donors.
Main Methods:
- Healthy donors were stratified into groups based on annual plateletpheresis donation frequency (5, 10, 15, 20 donations).
- Blood samples were collected pre-donation and at 30 minutes, 7 days, and 14 days post-donation.
- Coagulation time, platelet function, plasma protein, and serum iron were analyzed.
Main Results:
- Platelet function decreased and coagulation time prolonged at 30 minutes post-donation, recovering by 7 and 14 days, respectively.
- No significant differences in coagulation time or platelet function were observed between donors and controls.
- Plasma protein and serum iron remained within normal ranges, even in high-frequency donors (15-20 donations).
Conclusions:
- Plateletpheresis donation causes temporary, reversible changes in platelet function and coagulation.
- The frequency of platelet donation does not appear to have a long-term adverse effect on donor hematological parameters or iron status.
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