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Updated: Feb 28, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Cardiac Resynchronization Therapy for Heart Failure

Amole Ojo1, Sohaib Tariq1, Prakash Harikrishnan1

  • 1Division of Cardiology, Westchester Medical Center, New York Medical College, 100 Woods Road, Valhalla, NY 10595, USA.

Interventional Cardiology Clinics
|June 11, 2017
PubMed

Insights

Cardiac resynchronization therapy (CRT) improves heart failure outcomes by optimizing left ventricular function and reducing mitral regurgitation in patients with left bundle branch block. It offers significant benefits, but patient selection is key for optimal response.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Heart failure with reduced ejection fraction (HFrEF) and ventricular dyssynchrony, often due to left bundle branch block (LBBB), are significant clinical challenges.
  • Cardiac resynchronization therapy (CRT) is a nonpharmacologic treatment option for selected HFrEF patients.

Purpose of the Study:

  • To review the rationale, effects, and indications for CRT in heart failure patients.
  • To discuss patient characteristics predicting CRT response and strategies for nonresponders.

Main Methods:

  • Review of existing literature on CRT mechanisms, efficacy, and patient selection.
  • Analysis of studies investigating echocardiographic and clinical predictors of CRT response.

Main Results:

  • CRT can lead to reverse remodeling, increased ejection fraction (EF), and decreased mitral regurgitation severity.
  • Specific patient characteristics, such as LBBB morphology and QRS duration, predict CRT response.

Conclusions:

  • CRT is a valuable therapy for appropriately selected heart failure patients with LBBB.
  • Understanding response predictors is crucial for optimizing CRT outcomes and managing nonresponders.

Keywords:
Biventricular pacingCardiac resynchronization therapyDyssynchronyHeart failure with reduced ejection fraction

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