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Related Experiment Video

Updated: Feb 28, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Overcoming immunosuppression in bone metastases.

Zachary Z Reinstein¹, Sahithi Pamarthy², Vinay Sagar²

¹Developmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of Medicine, Chicago, USA; The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 86402, USA.

Critical Reviews in Oncology/Hematology

|June 11, 2017

Summary

This summary is machine-generated.

Bone metastases, common in advanced cancers, cause significant morbidity. Understanding the tumor-bone microenvironment and exploring novel therapies like immunotherapies and targeted treatments are key to improving patient outcomes.

Keywords:

Bone metastases bone metastatic disease immunosuppression skeletal-related events

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Area of Science:

Oncology
Cancer Metastasis Research
Immunotherapy

Background:

Bone metastases affect up to 70% of advanced prostate and breast cancers.
Bone metastases are linked to substantial patient morbidity.
The tumor-bone microenvironment involves immunosuppressive mechanisms.

Purpose of the Study:

To review current treatments for bone metastatic disease.
To explore novel therapeutic strategies targeting the tumor-bone microenvironment.
To inform the development of new therapies for bone metastases.

Main Methods:

Review of current standard of care for bone metastases.
Analysis of novel treatment options including immunotherapies, cryoablation, and targeted therapies.
Evaluation of preclinical and clinical studies on combinatorial strategies.

Main Results:

Combinatorial treatments show promise in overcoming the suppressive tumor-bone microenvironment.
Targeted therapies and immunotherapies are emerging as effective options.
Novel strategies aim to improve the treatment of bone metastases.

Conclusions:

Understanding the tumor-bone microenvironment is critical for developing effective therapies.
Combinatorial approaches combining targeted therapies and immunotherapies hold significant potential.
Further research into novel treatments is essential for improving outcomes in patients with bone metastases.