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Published on: February 8, 2017
Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges
Rajendran J C Bose1, Rramaswamy Ravikumar2, Vengadeshprabu Karuppagounder3
1School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea.
Abstract:
With rapid advances in nanomedicine, lipid-polymer hybrid nanoparticles (LPHNPs) have emerged as promising nanocarriers for several biomedical applications, including therapeutics delivery and biomedical imaging. Significant research has been dedicated to biomimetic or targeting functionalization, as well as controlled and image-guided drug-release capabilities. Despite this research, the clinical translation of LPHNP-mediated therapeutics delivery has progressed incrementally. In this review, we discuss the recent advances in and challenges to the development and application of LPHNPs, present examples to demonstrate the advantages of LPHNPs in therapeutics delivery and imaging applications, and discuss the translational obstacles to LPHNP technology.
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