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Related Concept Videos

Carbon-dioxide Fixation01:28

Carbon-dioxide Fixation

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Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
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"In-loop" [11 C]CO2 fixation: Prototype and proof of concept.

Kenneth Dahl1, Thomas L Collier1,2, Ran Cheng1

  • 1Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, and Department of Radiology, Harvard Medical School, Boston, MA, USA.

Journal of Labelled Compounds & Radiopharmaceuticals
|June 11, 2017
PubMed
Summary

This study introduces a simple and efficient "in-loop" apparatus for synthesizing carbon-11 labeled radiotracers using carbon dioxide fixation. The method enables robust production of essential PET imaging agents.

Keywords:
CO2-fixationcarbon-11carbonylationloop

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Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
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Area of Science:

  • Radiochemistry
  • Nuclear Medicine
  • Organic Synthesis

Background:

  • Carbon-11 labeled carbon dioxide ([11C]CO2) is a crucial precursor for synthesizing positron emission tomography (PET) radiotracers.
  • Direct [11C]CO2 fixation offers a streamlined approach for incorporating the 11C label into various molecular structures.

Purpose of the Study:

  • To develop and validate an "in-loop" apparatus for robust and reproducible synthesis of [11C]carbonyl-based radiotracers.
  • To demonstrate the utility of the developed method for producing clinically relevant PET imaging agents.

Main Methods:

  • Development of an "in-loop" apparatus utilizing [11C]CO2 fixation technology.
  • Synthesis of model compounds including carbamates, symmetrical and unsymmetrical ureas.
  • Application of the method for synthesizing a monoamine oxidase B inhibitor ([11C]SL25.1188) and novel fatty acid amide hydrolase inhibitors.

Main Results:

  • The "in-loop" [11C]CO2 fixation method is simple, efficient, and operates at ambient conditions.
  • Successful synthesis of various [11C]carbonyl-labeled compounds, including carbamates and ureas.
  • High yields and purity (>99%) of radiotracers were achieved, with molar radioactivity ≥80 GBq/μmol.

Conclusions:

  • The developed "in-loop" apparatus provides a reliable and efficient platform for the synthesis of [11C]carbonyl radiotracers.
  • This method facilitates the production of diverse PET imaging agents, including novel inhibitors and established tracers.
  • The synthesized radiotracers demonstrate high quality suitable for clinical applications in PET imaging.