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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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Malondialdehyde: A novel predictive biomarker for post-stroke depression.
Zhihua Liu1, Zhuoying Zhu1, Jiyun Zhao1
1Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Journal of Affective Disorders
|June 11, 2017
Summary
Elevated malondialdehyde (MDA) in stroke patients is linked to a higher risk of developing post-stroke depression (PSD). This biomarker may aid in diagnosing PSD, particularly after minor strokes.
Area of Science:
- Neuroscience
- Biochemistry
- Clinical Medicine
Background:
- Stroke is associated with oxidative stress, but its connection to post-stroke depression (PSD) is unclear.
- This study investigates the relationship between oxidative stress biomarkers and PSD.
Purpose of the Study:
- To determine if oxidative stress markers are associated with depression in acute stroke patients.
- To identify potential biomarkers for predicting PSD.
Main Methods:
- 216 acute stroke patients and 100 controls were recruited.
- Serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) were measured.
- Patients were assessed for depression (PSD group vs. non-PSD group).
Main Results:
- Serum MDA levels positively correlated with depression scores (r=0.536, p<0.001).
- MDA levels ≥ 2.898 nmol/ml were identified as an independent predictor of PSD (OR=24.295).
- The optimal cutoff for MDA showed high sensitivity (77.9%) and specificity (81.1%) for PSD diagnosis.
Conclusions:
- Elevated serum MDA levels upon admission are associated with an increased risk of PSD.
- MDA shows potential as an early diagnostic marker for depression following acute stroke, especially minor stroke.
