Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

11.4K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
11.4K
Antimicrobial Proteins01:23

Antimicrobial Proteins

14.8K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.1K
Overview
85.1K
Humoral Immune Responses01:36

Humoral Immune Responses

84.7K
Overview
84.7K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.5K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.5K
Antibody Actions01:26

Antibody Actions

3.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

ISG15 orchestrates dynamic crosstalk between mitochondrial fat oxidation and type 1 interferon in myeloid cells.

bioRxiv : the preprint server for biology·2026
Same author

A cut above: atypical proteolysis endows complement C3 with non-canonical immune activities.

The EMBO journal·2025
Same author

A CD4<sup>+</sup> T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction.

Immunity·2025
Same author

Complementing Anticancer Therapy: Antibody-Drug Conjugates Targeting CD46 as Prostate Cancer Treatment.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025
Same author

Inside job: Roles of intracellular C3.

The Journal of allergy and clinical immunology·2025

Related Experiment Video

Updated: Feb 28, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K

Intracellular complement - the complosome - in immune cell regulation.

Giuseppina Arbore1, Claudia Kemper2, Martin Kolev1

  • 1Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.

Molecular Immunology
|June 12, 2017
PubMed
Summary
This summary is machine-generated.

The complement system, once thought to be only in blood, also functions inside cells. This intracellular complement, or complosome, impacts cell metabolism and pathogen defense.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.3K
Real-time Live Imaging of T-cell Signaling Complex Formation
10:31

Real-time Live Imaging of T-cell Signaling Complex Formation

Published on: June 23, 2013

14.6K

Related Experiment Videos

Last Updated: Feb 28, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.3K
Real-time Live Imaging of T-cell Signaling Complex Formation
10:31

Real-time Live Imaging of T-cell Signaling Complex Formation

Published on: June 23, 2013

14.6K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The complement system is a key part of innate immunity, historically viewed as a serum-based defense against pathogens.
  • It comprises over 50 proteins involved in pathogen recognition, elimination, and removal of cellular debris.
  • Recent evidence reveals complement's role beyond serum, including local tissue and intracellular activation.

Purpose of the Study:

  • To explore novel aspects of intracellular complement activation.
  • To discuss the unexpected roles of the intracellular complement system (complosome) in basic cellular processes.
  • To examine the implications of complosome existence for host defense against intracellular pathogens.

Main Methods:

  • Review of experimental and clinical evidence.
  • Analysis of current literature on complement system function.
  • Discussion of emerging concepts in cellular immunology.

Main Results:

  • Intracellular complement activation (complosome) significantly impacts normal cell physiology.
  • The complosome plays unexpected roles in fundamental cellular processes, including metabolism.
  • Evidence suggests intracellular complement is involved in host defense against intracellular pathogens like viruses.

Conclusions:

  • The complement system's functions extend beyond extracellular defense into intracellular regulation.
  • Intracellular complement activation (complosome) represents a paradigm shift in understanding innate immunity.
  • Further research into the complosome is crucial for understanding cellular homeostasis and host-pathogen interactions.