Studies of hepatic tolerance of polyvinylpyrrolidone in the rat

Intraperitoneal polyvinylpyrrolidone in amounts much larger than used in povidone-iodine for peritonitis or for adhesion prophylaxis was administered to rats. No adverse effects on hepatic reticulo-endothelial function could be detected using dynamic hepatic scintigraphy and fewer histochemical changes occurred than expected.