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Obstacles, Opportunities and Priorities for Advancing Metastatic Breast Cancer Research
Margaret Flowers1, Stephanie Birkey Reffey2, Shirley A Mertz3
1Breast Cancer Research Foundation, New York, New York. mflowers@bcrfcure.org.
Abstract:
In January 2016, the Metastatic Breast Cancer Alliance (the Alliance) convened a think tank of stakeholders from academia, government, industry, and patient advocacy to discuss gaps and opportunities in clinical and translational research in metastatic breast cancer. Priorities that emerged from the meeting included the following: the need for innovative preclinical model systems to study metastatic disease; increased sharing of resources and data; collaboration across cancer care teams and scientists; biorepositories for studies to identify biomarkers for treatment response; creation of patient registries to increase access to clinical trials and tissue procurement; and redesign of clinical trials in metastatic breast cancer. Cancer Res; 77(13); 3386-90. ©2017 AACR.
Insights
Stakeholders identified key research priorities for metastatic breast cancer, including better preclinical models, data sharing, and improved clinical trial design. These advancements aim to accelerate progress in understanding and treating metastatic breast cancer.
Area of Science:
- Oncology
- Translational Research
- Cancer Metastasis
Background:
- The Metastatic Breast Cancer Alliance convened a think tank in January 2016.
- Stakeholders included academia, government, industry, and patient advocacy groups.
- The meeting focused on identifying gaps and opportunities in metastatic breast cancer research.
Framework:
- Need for innovative preclinical model systems to study metastatic disease.
- Importance of increased sharing of resources and data among researchers.
- Emphasis on collaboration across multidisciplinary cancer care teams and scientists.
Implementation:
- Establishment of biorepositories for biomarker discovery related to treatment response.
- Creation of patient registries to enhance access to clinical trials and tissue procurement.
- Redesign of clinical trials specifically for metastatic breast cancer.
Implications:
- Addressing identified gaps can accelerate progress in metastatic breast cancer research.
- Enhanced collaboration and data sharing are crucial for future discoveries.
- Improved preclinical models and clinical trial designs will benefit patient outcomes.
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