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Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
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Disease modeling in genetic kidney diseases: mice
Andreas F Hofmeister1, Martin Kömhoff2, Stefanie Weber2
1Department of Internal Medicine and Nephrology, University Hospital Giessen and Marburg, Philipps-University Marburg, Baldingerstrasse 1, 35033, Marburg, Germany.
Cell and Tissue Research
|June 12, 2017
Summary
Mice are crucial for studying genetic kidney diseases, with advanced technologies like CRISPR-Cas enabling more sophisticated models. These models enhance our understanding of disease mechanisms and potential therapies for inherited renal conditions.
Area of Science:
- Nephrology
- Genetics
- Animal Models
Background:
- Mice are vital mammalian models for human genetic kidney diseases due to ease of breeding and short reproductive cycles.
- Advancements in molecular biology have led to sophisticated mouse models with cell-specific, tissue-specific, and time-dependent gene targeting capabilities.
Purpose of the Study:
- To review mouse models developed for studying monogenic human kidney diseases.
- To provide an overview of well-established renal pathologies and their corresponding mouse models.
Main Methods:
- Focus on mouse models for monogenic inherited kidney diseases.
- Discusses classic gene knockout and transgenic models.
- Highlights the impact of genome-editing technologies like CRISPR-Cas, ZFNs, and TALENs.
Main Results:
- Sophisticated mouse models are expanding the "tool set" for studying inherited kidney diseases.
- These models allow detailed investigation into gene function, disease mechanisms, and therapeutic responses.
- Knockout and transgenic models provide insights into genotype-phenotype correlations in renal diseases.
Conclusions:
- Technological advancements in mouse modeling promise deeper understanding of inherited kidney diseases.
- Mouse models are essential for elucidating the impact of genetic variations on kidney disorders.
- This review offers a balanced perspective on key mouse models for monogenic renal pathologies.
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