Related Experiment Video
Updated: Feb 28, 2026
08:59
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
11.4K
Head and Neck Cancer Pain
1University of California Los Angeles, Comprehensive Pain Center, 1245 16th Street, Suite 225, Santa Monica, CA 90404, USA.
Otolaryngologic Clinics of North America
|June 13, 2017
Summary
Managing head and neck cancer pain requires understanding its complex causes and available treatments. A multimodal approach combining pharmacotherapies and nonpharmacologic methods is recommended for effective pain management.
Area of Science:
- Oncology
- Pain Medicine
- Palliative Care
Background:
- Head and neck cancer is a leading cause of patient morbidity.
- Cancer treatments often exacerbate pain, impacting quality of life.
- Effective pain management is crucial for patient well-being.
Purpose of the Study:
- To outline strategies for managing pain in head and neck cancer patients.
- To emphasize the importance of understanding pain mechanisms.
- To highlight the role of pharmacotherapies and nonpharmacologic interventions.
Main Methods:
- Review of multifactorial pain mechanisms in head and neck cancer.
- Analysis of available pharmacotherapeutic options.
- Consideration of nonpharmacologic adjunctive therapies.
Main Results:
- Pain in head and neck cancer is complex and multifactorial.
- A variety of pharmacotherapies can be utilized.
- Multimodal and nonpharmacologic approaches enhance pain control.
Conclusions:
- Effective management of head and neck cancer pain necessitates a comprehensive understanding of its origins.
- A multimodal therapeutic strategy, integrating pharmacologic and nonpharmacologic treatments, is essential.
- Experienced practitioners are key to optimizing pain management outcomes.
Keywords:
Acute postsurgical painHead and neck cancer painMucositisMultimodal therapyNeuropathic painOpioid managementMore Related Videos
Related Concept Videos
01:29Blood and Nerve Supply to the Bones
14.3K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.3K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
691
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
691
01:19Veins of Head and Neck
6.3K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
6.3K
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
744
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
744
01:26Arteries of the Head and Neck
3.9K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
3.9K
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
864
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
864