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Engineering biological systems using automated biofoundries.

Ran Chao1, Shekhar Mishra1, Tong Si2

  • 1Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.

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Biological foundries automate engineering cycles for genetic circuits and microbial cell factories. This accelerates biotechnology and bioengineering R&D, overcoming traditional slow and costly methods.

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Area of Science:

  • Biotechnology and Bioengineering
  • Synthetic Biology
  • Automation in Life Sciences

Background:

  • Engineered biological systems offer solutions to societal challenges.
  • Traditional R&D processes in biotechnology are slow, expensive, and inconsistent.
  • These limitations hinder progress in bioengineering.

Purpose of the Study:

  • To review enabling technologies for biological foundries.
  • To summarize early successes of biofoundries.
  • To identify remaining challenges in biofoundry development.

Main Methods:

  • Review of current literature on biofoundry technologies.
  • Analysis of automation strategies in design-build-test cycles.
  • Synthesis of case studies on biofoundry applications.

Main Results:

  • Biofoundries utilize automation to accelerate the engineering of biological systems.
  • Key technologies include robotic liquid handling, DNA synthesis, and data management.
  • Early successes demonstrate increased throughput and reproducibility.

Conclusions:

  • Biological foundries are crucial for advancing biotechnology and bioengineering.
  • Automation is key to overcoming R&D bottlenecks.
  • Continued development is needed to address remaining challenges and fully realize potential.